DR-162 Genomic and transcriptomic analysis of e-cadherin mutated breast cancer

There are different types of breast cancer, one is referred to as Invasive Lobular Carcinoma (ILC). ILC accounts for around 10% of breast cancers, and while considered a distinct tumor subclass, these patients are treated identical as the predominant subclass Invasive Ductal Carcinoma (IDC). ILC cancers have a very specific feature: almost all of these tumors have a mutation in a gene called Ecadherin. Using this mutation to identify ILC, we aim to compare ILC and IDC breast cancer. With a better understanding of ILC, future therapeutic options could be better finetuned for this distinct breast cancer subclass.

Wilbert Zwart Netherlands Cancer Institute the Netherlands