DR-168 Defining mutational signatures of childhood cancer treatments

Numerous environmental triggers have been found to leave a mutational footprint on the DNA of human cancers. In our lab, we want to identify how the treatments of pediatric cancer contribute to the development of second cancers. To robustly link a treatment to a mutational footprint found in pediatric second cancers, we want to investigate the mutations in as many tumors and tumor types that have undergone similar treatment and search for the same signature. Hereby, we identify the treatments with the highest contribution to the development of second cancers, which can be taken into account in new treatment regimens.

Ruben van Boxtel Prinses Maxima Centrum Netherlands