DR-172 Detecting RET gene fusions in lung cancer: multicenter experience and comparison of molecular testing modalities

RET fusion gene testing will soon become very important for selection of lung cancer patients for treatment with the novel tyrosine kinase inhibitor, selpercatinib. In our diagnostic setting we observed that RET in situ hybridization (ISH) testing, a molecular test that is used worldwide for screening lung cancer for genomic breaks at the RET locus often yields false-positive results. As a result patients might be(come) treated wrongly. To explain the many false-positive RET ISH results, we would like to investigate WGS data for the presence of structural variations at the RET locus (versus ALK and ROS1 loci) in lung cancers.

Erik Jan Dubbink Erasmus MC the Netherlands