DR-232 Whole Genome Sequencing can classify diagnostically challenging tumors.

Cancer of Unknown Primary (CUP) accounts for approximately 3% of all metastatic cancers. Despite modern imaging techniques and extensive pathology work-up in CUPs, tumor origin remains unknown in the majority of these patients. Large-scale genome sequencing studies have revealed that tumor types can be classified based on distinct patterns of somatic variants and other genomic characteristics. We aim to investigate the clinical value of genome-driven tumor type prediction using whole genome sequencing (WGS) in the diagnostic workup of patients with CUPs and other tumors that are challenging to diagnose.

Kim Monkhorst, Netherlands Cancer Institute, the Netherlands