DR-283 The genetic basis of disease progression and drug resistance in advanced metastatic cancer

Metastasis is the primary cause of death in cancer and the mechanisms of cancer progression and metastasis are varied and complex. By analyzing Whole Genome Sequencing (WGS) and RNA-sequencing of in-house metastatic cancer patients, we identified a minimal universal set of genomic alterations- including somatic mutation, copy number, and structural rearrangement- that could explain disease progression and drug resistance against various therapies. The overarching goal is to develop a composite score that could reliably predict progression rate and response to different treatment modalities.

Arul Chinnaiyan, University of Michigan, USA