Dr-304 Characterization of genomic alterations in metastatic cutaneous squamous cell carcinoma and basal cell carcinoma

Every year  >14,000 patients are diagnosed with cutaneous squamous cell carcinoma (cSCC) and > 35,000 new patients with basal cell carcinoma (BCC). cSCCs metastasize in ~2% of patients and BCCs rarely metastasize. We will investigate if predictive information about metastatic risk is present in the primary tumours. We will 1) characterize the genomic alterations in cSCC/BCC metastatic samples and 2) confirm that genes that were previously identified to be related to the metastatic potential of cSCC/BCC are also mutated in metastatic HMF samples. The previously identified genes will be extended with the new genomic alterations and validated in another cohort.

Loes Zandwijk – Hollestein, Erasmus MC, The Netherlands