DR-324 Identification of non-coding aberrations that drive cancer

The aim of this project is to perform pan-cancer and cancer-type specific analyses to gain insight into molecular aetiology, molecular pathology, and underlying biology of diverse tumour types, in order to ultimately inform both tumour stratification and aid in the identification of novel therapeutic targets and targeted interventions.

We wish to integrate whole genome sequencing and clinical information to investigate the interplay between regions of the genome associated with cancer risk and recurrent non-coding somatic mutations present in these regions. This data will be utilised to identify similarities and differences both within tumour specific subtypes and across multiple tumour types.

Sarah Maguire, The Queen’s University Belfast, United Kingdom