DR-325 Deciphering the role of Trem1 signaling in breast cancer metastasis

Trem1 is an LPS dimerizing receptor that is mainly involved in bacterial and danger-damage-associated signals. Yet, its role in cancer has remained unexplored. Here we aim to uncover whether the expression of Trem1 is predictive of metastasis outgrowth and whether its downstream signaling promotes a suppressive phenotype in myeloid cells, particularly in neutrophils.

Maria Casanova, Spanish National Cancer Research Center (CNIO), Spain