DR-327 Copy number features as a novel biomarker of homologous recombination (HR) status in HR deficient (HRD) tumors

Homologous recombination deficiency (HRD) is one of the driving factors of tumorigenesis as leads to damage in the repair process of DNA double-strand breaks resulting in chromosome instability (CI) and large genomic alterations called “genomic scars”. As a consequence of this CI, gain and loss of chromosomal regions can be observed as copy number alterations (CNA). The purpose of our project is to identify CNA features as a novel biomarker of HR status.

Ana Vivancos, Vall d’Hebron Institute of Oncology (VHIO), Spain