DR-331 The landscape of germline-somatic interactions

Summary = Inherited genetic factors are known to contribute to the risk of developing different types of tumors and to influence the potential to respond to cancer therapies. However, other than a few well-established cancer predisposition genes, inherited factors are largely ignored by precision cancer medicine. We have previously shown that cancer-relevant inherited genetic factors can be detected by studying interactions between tumor evolution and genetic background using paired tumor normal genomic data. We hypothesize that this information can be used to improve projections about cancer risk, implicate novel therapeutic targets and predict potential to respond to therapy.

Hannah Carter, University of California San Diego, USA