DR-336 Genomic signatures of cancer therapies

Cancer is a disease characterized by genomic alterations, including mutations, copy number variations, and structural variants. These genomic alterations can dynamically change during tumor evolution and may be impacted by therapy. Recent studies investigating post-treatment patient samples have identified therapy-associated mutational signatures, particularly for chemotherapy and radiotherapy, but the effects on copy number and structural variants are largely unknown. The goal is to identify the full spectrum of genomic signatures associated with cancer treatment, as this has high clinical relevance and could lead to novel therapeutic opportunities.

Emre Kocakavuk, University Hospital Essen, Germany