DR-338 Systematic discovery and characterization of cancer-specific expression patterns

Cancer is driven by genetic changes, and multiple genes that have oncogenic and tumor suppressive potential have been widely investigated. We have recently developed a novel bioinformatics method to analyze transcriptomic data from cancer and normal tissues and to reveal cancer-specific expression patterns. However, their biological relevance still needs to be elucidated. We would like to investigate the association between such cancer-specific expression patterns and somatic alterations for each cancer type using the Hartwig Medical Foundation dataset. This study will elucidate the characteristics and biology of cancer-specific expression patterns.

Keisuke Kataoka, National Cancer Center, Japan