DR-361 A systematic analysis for the cancer fitness landscape between primary and metastatic tumors

We aim to demonstrate that the optimal activity-fitness level (cancer fitness) of cancer genes can vary depending on the tumor type or conditions (i.e., primary vs. metastatic). Our goal is to elucidate hidden differences that are not observable from single-gene level analysis. To achieve this, sequencing data from large-scale metastatic samples (such as those from the Hartwig Foundation) will be crucial, as currently available datasets are heavily biased toward primary tumors.

Solip Park, Spanish National Cancer Research Center (CNIO), Spain