DR-370 Molecular mechanisms underlying the metastatic progression

Metastasis is responsible for the failure of cancer treatment and patient mortality. Thanks to the unprecedented opportunity to study the association between occurrence of cancer-associated mutations and the pathways through which DNA is repaired when it is damaged at specific sites, we will use genomic data from Hartwig Medical Foundation, donated from breast cancer patients, to investigate the molecular mechanisms involved in the progression of carcinoma cells in gaining metastatic properties.

Yinxiu Zhan, Istituto Europeo di Oncologia, Italy