DR-435 The role of SMC5/6 in colorectal cancer genome stability

Colorectal cancers have high levels of mutations and genome instability. While this enables tumors to become metastatic, it also may cause sensitivity of tumors to therapy. We have identified a genome maintenance complex, SMC5/6, which is dysfunctional in many colorectal cancers, and leads to increased tumor mutational burdens. We are now interested to investigate how dysfunction of SMC5/6 in CRC impacts response to therapy. 

Abby Green, Washington University School of Medicine, United States of America