DR-547 Whole Genome Sequencing of Neuroendocrine Malignancies

Neuroendocrine malignancies encompass a rare form of cancer that can arise throughout the body. Clinical and molecular heterogeneity of neuroendocrine tumors and carcinomas make it difficult to identify the optimal treatment strategy for individual patients. This project combines whole genome sequencing (WGS) of tumors and matched normal (germline) DNA with clinical information to characterize the genomic landscape of neuroendocrine malignancies. By identifying genomic alterations and linking them to clinical outcomes, we aim to improve our understanding of disease biology and support the development of accurate diagnostic approaches and personalized treatment strategies for patients with neuroendocrine malignancies.

Margot Tesselaar, Netherlands Cancer Institute, the Netherlands