CIBRA identifies genomic alterations with a system-wide impact on tumor biology
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CIBRA identifies genomic alterations with a system-wide impact on tumor biology
Soufyan Lakbir, Caterina Buranelli, Gerrit A Meijer, Jaap Heringa, Remond J A Fijneman & Sanne Abeln Bioinformatics, 2024, DOI
Long deletion signatures in repetitive genomic regions track somatic evolution and enable sensitive detection of microsatellite instability
Qingli Guo, Jacob Househam, Eszter Lakatos, Salpie Nowinski, Ibrahim Al Bakir, Heather Grant, Vickna Balarajah, Christine S. Hughes, Luis Zapata, …
Selective pressures of platinum compounds shape the evolution of therapy-related myeloid neoplasms
Eline J. M. Bertrums, Jurrian K. De Kanter, Lucca L. M. Derks, Mark Verheul, Laurianne Trabut, Markus J. Van Roosmalen, …
Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivity
Kathleen E. Houlahan, Aziz Khan, Noah F. Greenwald, Cristina Sotomayor Vivas, Robert B. West, Michael Angelo & Christina Curtis Science, …
Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis
Santiago Demajo, Joan E. Ramis-Zaldivar, Ferran Muiños, Miguel L. Grau, Maria Andrianova, Núria López-Bigas & Abel González-Pérez Cancer Discovery, 2024, …
The multitarget faecal immunochemical test for improving stool-based colorectal cancer screening programmes: a Dutch population-based, paired-design, intervention study
Pieter H A Wisse, Willemijn De Klaver, Francine Van Wifferen, Frejanne G Van Maaren-Meijer, Huub E Van Ingen, Lana Meiqari, …
Copy number losses of oncogenes and gains of tumor suppressor genes generate common driver mutations
Elizaveta Besedina & Fran Supek Nature Communications, 2024, DOI
Genomic deletions explain the generation of alternative BRAF isoforms conferring resistance to MAPK inhibitors in melanoma
Francisco Aya, Pablo Lanuza-Gracia, Abel González-Pérez, Sophie Bonnal, Estefania Mancini, Nuria López-Bigas, Ana Arance & Juan Valcárcel Cell Reports, 2024, …
EXO1 protects BRCA1-deficient cells against toxic DNA lesions
Bert Van De Kooij, Anne Schreuder, Raphael Pavani, Veronica Garzero, Sidrit Uruci, Tiemen J. Wendel, Arne Van Hoeck, Marta San …
Improved detection of colibactin-induced mutations by genotoxic E. coli in organoids and colorectal cancer
Axel Rosendahl Huber, Cayetano Pleguezuelos-Manzano, Jens Puschhof, Joske Ubels, Charelle Boot, Aurelia Saftien, Mark Verheul, Laurianne T. Trabut, Niels Groenen, …
Gene-expression-based T-Cell-to-Stroma Enrichment (TSE) score predicts response to immune checkpoint inhibitors in urothelial cancer
Maud Rijnders, J. Alberto Nakauma-González, Debbie G. J. Robbrecht, Alberto Gil-Jimenez, Hayri E. Balcioglu, Astrid A. M. Oostvogels, Maureen J. …
Five latent factors underlie response to immunotherapy
Joseph Usset, Axel Rosendahl Huber, Maria A. Andrianova, Eduard Batlle, Joan Carles, Edwin Cuppen, Elena Elez, Enriqueta Felip, Marina Gómez-Rey, …
Deze complete DNA-test maakt de individuele behandeling mogelijk en beperkt daarmee onwenselijke bijwerkingen.