Combining genomic biomarkers to guide immunotherapy in non-small cell lung cancer
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Combining genomic biomarkers to guide immunotherapy in non-small cell lung cancer
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Whole-genome mapping of APOBEC mutagenesis in metastatic urothelial carcinoma identifies driver hotspot mutations and a novel mutational signature
J. Alberto Nakauma-González, Maud Rijnders, Minouk T. W. Noordsij, John W. M. Martens, Astrid A. M. van der Veldt, Martijn …
Transcriptome-based classification to predict FOLFIRINOX response in a real-world metastatic pancreatic cancer cohort
Marjolein F. Lansbergen, Mark P.G. Dings, Paul Manoukian, Arantza Fariña, Cynthia Waasdorp, Gerrit K.J. Hooijer, Joanne Verheij, Jan Koster, Danny …
EXO1 protects BRCA1-deficient cells against toxic DNA lesions
Bert Van De Kooij, Anne Schreuder, Raphael Pavani, Veronica Garzero, Sidrit Uruci, Tiemen J. Wendel, Arne Van Hoeck, Marta San …
Long deletion signatures in repetitive genomic regions track somatic evolution and enable sensitive detection of microsatellite instability
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Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis
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Improved detection of colibactin-induced mutations by genotoxic E. coli in organoids and colorectal cancer
Axel Rosendahl Huber, Cayetano Pleguezuelos-Manzano, Jens Puschhof, Joske Ubels, Charelle Boot, Aurelia Saftien, Mark Verheul, Laurianne T. Trabut, Niels Groenen, …
Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivity
Kathleen E. Houlahan, Aziz Khan, Noah F. Greenwald, Cristina Sotomayor Vivas, Robert B. West, Michael Angelo & Christina Curtis Science, …
Mapping extrachromosomal DNA amplifications during cancer progression
Hoon Kim, Soyeon Kim, Taylor Wade, Eunchae Yeo, Anuja Lipsa, Anna Golebiewska, Kevin C. Johnson, Sepil An, Junyong Ko, Yoonjoo …
Copy number losses of oncogenes and gains of tumor suppressor genes generate common driver mutations
Elizaveta Besedina & Fran Supek Nature Communications, 2024, DOI
In ons vak is het heel belangrijk om naast de kennis over de patiënt meer kennis te hebben van de tumor van de patiënt.