Mapping extrachromosomal DNA amplifications during cancer progression

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Mapping extrachromosomal DNA amplifications during cancer progression

15-10-2024

Hoon Kim, Soyeon Kim, Taylor Wade, Eunchae Yeo, Anuja Lipsa, Anna Golebiewska, Kevin C. Johnson, Sepil An, Junyong Ko, Yoonjoo Nam, Hwa Yeon Lee, Seunghyun Kang, Heesuk Chung, Simone P. Niclou, Hyo-Eun Moon, Sun Ha …

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Copy number losses of oncogenes and gains of tumor suppressor genes generate common driver mutations

27-09-2024

Elizaveta Besedina, Fran Supek Nature Communications, 2024, DOI: 10.1038/s41467-024-50552-1

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Transcriptome-based classification to predict FOLFIRINOX response in a real-world metastatic pancreatic cancer cohort

10-09-2024

Marjolein F. Lansbergen, Mark P.G. Dings, Paul Manoukian, Arantza Fariñac, Cynthia Waasdorp, Gerrit K.J. Hooijer, Joanne Verheij, Jan Koster, Danny A. Zwijnenburg, Johanna W. Wilmink, Jan Paul Medema, Frederike Dijke, Hanneke W.M. van …

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Whole-genome mapping of APOBEC mutagenesis in metastatic urothelial carcinoma identifies driver hotspot mutations and a novel mutational signature

22-04-2024

J. Alberto Nakauma-González, Maud Rijnders, Minouk T.W. Noordsij, John W.M. Martens, Astrid A.M. van der Veldt, Martijn P.J. Lolkema, Joost …

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Estimating the Prognostic Value of the NTRK Fusion Biomarker for Comparative Effectiveness Research in The Netherlands

22-04-2024

Irene Santi, Heleen Vellekoop, Matthijs M Versteegh, Simone A Huygens, Winand N. M. Dinjens, Maureen Rutten‑van Mölken Molecular Diagnosis & …

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Genomic deletions explain the generation of alternative BRAF isoforms conferring resistance to MAPK inhibitors in melanoma

19-04-2024

Francisco Aya, Pablo Lanuza-Gracia, Abel González-Pérez, Sophie Bonnal, Estefania Mancini, Nuria López-Bigas, Ana Arance, Juan Valcárcel Cell Reports, 2024, DOI: …

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A pan-cancer analysis of the microbiome in metastatic cancer

19-04-2024

Thomas W. Battaglia, Iris L. Mimpen, Joleen J.H. Traets, Arne Van Hoeck, Laurien J. Zeverijn, Birgit S. Geurts, Gijs F. …

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Impact of genetic counseling strategy on diagnostic yield and workload for genome-sequencing-based tumor diagnostics

12-03-2024

Roelof Koster, Luuk J. Schipper, Noor A.A. Giesbertz, Daphne Van Beek, Matías Mendeville, Kris G. Samsom, Efraim H. Rosenberg, Frans …

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The multitarget faecal immunochemical test for improving stool-based colorectal cancer screening programmes: a Dutch population-based, paired-design, intervention study

20-02-2024

Wisse PHA, de Klaver W, van Wifferen F, van Maaren-Meijer FG, van Ingen HE, Meiqari L, Huitink I, Bierkens M, …

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Gene-expression-based T-Cell-to-Stroma Enrichment (TSE) score predicts response to immune checkpoint inhibitors in urothelial cancer

20-02-2024

Rijnders M, Nakauma-González JA, Robbrecht DGJ, Gil-Jimenez A, Balcioglu HE, Oostvogels AAM, Aarts MJB, Boormans JL, Hamberg P, van der …

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Combining genomic biomarkers to guide immunotherapy in non-small cell lung cancer

05-02-2024

Joris van de Haar; Joanne M. Mankor; Karlijn Hummelink; Kim Monkhorst; Egbert F. Smit; Lodewyk F.A. Wessels; Edwin Cuppen; Joachim …

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EXO1 protects BRCA1-deficient cells against toxic DNA lesions

24-01-2024

Bert van de Kooij, Anne Schreuder, Raphael Pavani, Veronica Garzero, Sidrit Uruci, Tiemen J. Wendel, Arne van Hoeck, Marta San …

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