DR-270 Therapy resistance mechamisms in uterine cancers

This project will focus on treatment resistance mechanisms in uterine cancers to develop novel targeted treatments as adjuvants or combination therapy. By investigating pre- and post-treatment uterine biopsies by sequencing, we will detect treatment associated genomic alterations with a specific focus on large genomic re-arrangements. In order to identify actionable resistance drivers, we need to increase the sample size by including the Hartwig uterine samples. In addition, we will investigate the prevalence of detected uterine cancer drivers in non-uterine cancers.

Camilla Krakstad, University of Bergen, Norway