DR-215 Interplay between drug treatment and rearrangment occurrence

Cancer is driven by mutations in the genome. Several drugs, including some of the most widely used compound types, induce mutations and genomic instability, and tumor cells that survive drug treatment often involve substantial drug-induced mutations and rearrangements in the genome. Using the HMF data, we aim to study the regional context and genomic location of somatic alterations across different tumor types stratified by drug type, to identify therapy-related mutagenesis at the level of somatic rearrangements.

Joachim Weischenfeldt, Rigshospitalet, Denmark