DR-229 identifying patients that are resistant to EGFR-targeting therapy

EGFR-targeting therapies are used as anti-cancer agents. Not all patients respond well and side-effects can be significant. Therefore, biomarkers that identify those likely to respond have emerged and are used in daily practice. But even among patients positive for these biomarkers, response rates remain variable. We would like to use the HMF data of EGFR-treated patients to identify DNA alterations that are predictive of a poor therapy-response. As such, we aim to ‘fine-tune’ the molecular pre-screening of patients eligible for this therapy, thereby improving response rates and providing the best care for cancer patients.

Jeanine Roodhart Universtair Medisch Centrum Utrecht (UMCU) the Netherlands