DR-169 Assessing drug response in breast cancer tissue samples

Breast cancer (BC) is the most common malignancy among women, constituting the prominent cause of cancer-associated mortality. Despite considerable knowledge of the BC molecular subtypes, there is no strategy for accurate stratification of BC patients. The main purpose of this project is to identify genomic alterations that differentiate patients, who respond and who don’t respond to a particular treatment type. For this purpose, we will perform whole-genome sequencing data analyses on BC patients genomes downloaded from Hartwig Medical Foundation and build clinical predictor. This tool will help in treatment decision-making, indicating benefits and risks connected with a particular treatment type.

Pawel Zawadzki Adam Mickiewicz University in Poznań Poland