DR-136 Tracking cancer evolution from emergence to metastasis

We plan to investigate the evolution of lung tumours at different stages of cancer development. The molecular data used to track cancer evolution gives us information about the key genes and processes involved in the tumour’s ability to overcome the patient’s immune system and external treatments. With the data from the HMF we additionally plan to investigate such processes at later stages of cancer development. Specifically, we will explore the role of genes and processes relevant at early stages of cancer evolution and at later stages, after treatment. Ultimately, these data will inform the identification of new targets for a more personalised therapy and prognosis.

Nicholas McGranahan University College London United Kingdom