DR-102 Correlation analyses of genomic data, ctDNA and clinical data in patients with advanced/metastatic urothelial cell cancer (UCC) treated with anti-PD1 checkpoint inhibitors.

The treatment of bladder cancer patients with immunotherapy is a very promising and effective treatment. However, only a minority of patients responds to the treatment with only immune therapy (up to 30%). These patients benefit from this treatment and do not need other treatments, whereas other patients do need some other form of treatment. We have performed a study: the RESPONDER study to collect multiple different tissues from patients including a CPCT-02 biopsy. In this proposal we aim to combine the data on immune monitoring/ circulating tumor derived DNA (ctDNA) analysis and clinical outcome with the genomic data obtained by the HMF to improve the identification of those patients that are at risk of failing treatment and those patients that could be spared from potentially toxic combination treatments.

Martijn Lolkema Erasmus MC the Netherlands