DR-330 Enhancers driving oncogenes in ovarian cancer

Ovarian cancer is the most lethal gynecological cancer in the western world. It is typically diagnosed at a late stage and at the moment there is no definite therapy. To improve and individually tailor therapy, it will be essential to uncover molecular drivers of oncogenic transformation in those tumors. Preliminary data revealed involvement of mutations in non-coding regions of the genome, in so-called enhancer regions. Studying ovarian cancer data from the Hartwig Medical Foundation, will enable us to identify those enhancer driven ovarian cancers which is a necessary first step to understand the oncogenic transformation to ultimately develop better treatment.

Leonie Smeenk, Erasmus MC, the Netherlands