DR-035 Learning the subtypes of cancer

Histological, immunohistochemical and gene expression markers are routinely used to stratify tumours into clinically distinct subtypes, some of which have targeted therapies that improve prognosis. Recent work has shown that unsupervised clustering using genomic profiling can reveal novel subtypes with distinct clinical outcomes. We will explore if stratifying patients directly from whole genome mutation profiles can identify novel subtypes and driver pathways that could lead to improved personalised therapy opportunities.

David Wedge University of Oxford United Kingdom