DR-060 Whole genome Sequencing to estimate TEmozolomide Associated Response IN Gliomas (STEARING)

“Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults. Since 2005, standard treatment consists of surgery followed by radiation therapy with concurrent and adjuvant temozolomide chemotherapy, taking ± 8.5 months in total. Despite optimal treatment, GBM outcome is almost inevitably fatal, usually within 16 months after diagnosis. There is an urgent need to improve treatment of patients with GBM, both by selection of patients most likely to respond to standard therapy, as well as through the identification of novel targets for [combination] treatment.
Whole-genome sequencing is a personalized medicine approach that can be applied to characterize the complete DNA sequence of individual patient’s tumors. Thus far, tumor specimen of 80 patients with GBM have been collected in the Dutch Center for Personalized Cancer Treatment [CPCT] biopsy study, together with information on the response to temozolomide-based chemoradiation. In this research proposal, a multidisciplinary team of Dutch neurologists, oncologists and neuro-surgeons propose to investigate the relation between the genetic properties of these tumors and response to temozolomide-based treatment.”

Filip De Vos UMC Utrecht the Netherlands