DR-070 Mutational status of stage IV small intestinal neuroendocrine tumors and its effect on therapy and prognosis

“Small intestinal neuroendocrine tumors (SI-NETs) represent a heterogenous group of rare tumors. At time of diagnosis approximately 50% of patients present with metastasized disease (Frilling 2014)1. Patients with metastasized disease are (usually) ineligible for curative surgery and have few treatment options with limited survival benefit. Unraveling the molecular events underlying SI-NET tumorigenesis could facilitate the identification of therapeutic targets and improve prognosis. In order to expand the limited existing knowledge on molecular factors in SI-NETs and move towards personalized treatment, we would like to study somatic and germline mutations of SI-NETs by using DNA next generation sequencing.
1 Frilling A, Modlin I, Kidd M, Russel C, Breitenstein S, Salem R et al (2014). Recommendations for management of patients with neuroendocrine liver metastases. The Lancet Oncology15(1), pp. e8-e21
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Margot Tesselaar NKI/AvL the Netherlands