DR-086 Optimalisation of chemotherapy response in metastatic colorectal cancer patients based on a patient-specific cellular composition score.

The treatment of metastatic colorectal cancer (mCRC) is still based on traditional chemotherapies. mCRC is a very heterogeneous disease, and a tumor from a single patient might respond to one therapy, but not to the other. Unfortunately, personalized cancer treatment for chemotherapy is currently lacking, since we are not able to correctly predict chemotherapy response upfront. Consequently, patients do not always get the optimal (order of) treatment. By looking at the cellular composition of a tumor (i.e. all different cell types), we aim to optimize the chemotherapy choice and select the most effective therapy for every individual patient.

Emile Voest NKI/AvL the Netherlands