DR-147 An exploratory study on the prognostic and predictive value of the immune infiltrate in metastastic bladder cancer and its relation with other microenvironmental factors and long non-coding RNAs.

In urothelial cancer, prognosis and responsiveness to treatments, such as chemotherapy and checkpoint inhibitors, differs substantially between patients. Although urothelial cancer is known to be an immunogenic tumour, little is know about the prognostic and predictive value of the immune infiltrate in metastatic urothelial cancer. Here, we will use RNA sequencing data to infer immune cell composition and study its relation with clinical outcome, micronenvironmental factors and long non-coding RNAs. Identification of prognostic or predictive biomarkers is needed to tailor treatment to the individual patient. Moreover, a better understanding of factors that influence the immune infiltrate might provide a rationale for new treatment strategies.

Niven Mehra Radboudumc the Netherlands