DR-154 Understanding co-effect of inherited and somatic alterations in cancer

Recent studies emphasize the importance of combined effects of germline and somatic alterations in cancer. The aim of the project is to study how germline and somatic alterations contribute together to gene expression and drive glioma development. We will use next-generation sequencing data derived from matched normal and tumor samples of glioma patients. The data will be integrated with tissue- and tumor-specific data of regulatory elements to identify cancer-driving gene regulatory elements. The study is expected to produce novel findings, which have potential to be used in diagnostics and therapeutic applications to improve patient care.

Matti Nykter Tampere University Finland