DR-272 Uncovering the role of gut bacteria in colorectal cancer tumorigenesis and metastasis

Colorectal cancer (CRC) is the third most common cancer in men and second most common in women worldwide. The intestinal tract harbors approximately 1000 different species of microorganisms and CRC is not only a genetic disorder, but may also be related to the specific microbes. Characterization of transcriptomic data from both healthy and CRC patients has revealed a complex and symbiotic relationship between gut microbiota and host. Here, we aim to identify the dynamic interrelationships between bacteria and underlying genetic alterations in CRC to establish the mechanistic basis for developing novel treatment strategies for CRC.

Prasanta Dey, Rutgers Cancer Institute of New Jersey, USA