DR-274 Next generation CUP diagnostics by WGS by improving tumor classification categories and re-training

Cancer of unknown primary (CUP) has a worldwide incidence of 3-5% of all cancers diagnoses. The clinical problem of this group of patients involves long diagnostic period, limited treatment options (anti-cancer treatment is largely based on primary origin) and poor survival. Whole genome sequencing (WGS) helps these patients by both predicting the primary origin and finding all DNA alterations linked with targeted therapy. The Hartwig prediction algorithm of the tissue site of primary origin (CUPPA) is based on a reference dataset of tumors in the Hartwig database. We aim to improve the prediction algorithm by refining the classification of tumors within the reference dataset towards a more clinically relevant setup.

Petur Snaebjornsson, Netherlands Cancer Institute, the Netherlands