DR-279  Identification and validation of genomic and transcriptomic based biomarkers for organoid and patient response in a large colorectal cancer cohort

With this project, we aim to personalize cancer treatment and find new treatments for cancer sub-types by investigating the (expression of) genetic alterations of the tumor. We will compare genomic and transcriptomic data with patient and organoid response data, to find alterations that are related to treatment response. These profiles can be used as a predictive biomarker for treatment selection in the future. By integrating genomics/transcriptomics with organoid drug screens and patient response we can establish procedures for stratifying patients towards the most optimal treatment strategy. This will improve the quality of cancer care as patients don’t undergo treatments they will not likely benefit from.

Jeanine Roodhart, Universtair Medisch Centrum Utrecht (UMCU), the Netherlands