DR-342 Telomere fusions in metastatic tumors

Telomeres protect our genomesfrom deterioration and instability. A key aspect of telomere biology is the occurrence of telomere fusions, which happen when two chromosomes become physically connected at their tips. This can trigger a series of genomic rearrangements ultimately leading to malignant tumors. We will analyze the presence and rates of telomere fusions in metastatic tumors using WGS data. Additionally, we seek to develop a liquid biopsy analysis for metastasis based on the amount of telomere fusions in the blood of metastatic cancer patients. Understanding the contribution of telomere fusions to metastasis will be crucial in improving patient outcomes.

Ignacio Flores, Centro de Biología Molecular Severo Ochoa (CBMSO), Spain