DR-363 Identification of functional intergenic genomic fusions

Predicting the functional outcomes of genomic rearrangements is challenging due to the intricate nature of rearrangement patterns. Consequently, studies on genomic biomarkers for predicting drug responses have primarily concentrated on in-frame gene fusions. However, recent research has revealed that non-canonical types of genomic rearrangements in multiple cancer genes, which do not fall under the category of in-frame gene fusion, may also play a crucial functional role in facilitating tumor initiation and progression and serve as predictors for anti-cancer drug response. In this study, we aim to identify non-canonical types of functional genomic rearrangements, including intergenic fusions, by utilizing whole genome sequencing (WGS), RNA sequencing (RNA-seq), and treatment response data.

Jinhyuk Bhin, Yonsei University College of Medicine, South Korea