DR-419 Characterizing the role of cytidine deaminase in cancer progression and metastasis

The incidence of cancer is a major health problem worldwide, however the mechanistic basis of cancer development and intervention to prevent disease progression still remains elusive. This proposal investigates a mechanistic link between cancer progression and intrinsic cytidine deaminase activities that lead to increased somatic mutation. This could help to explain the detailed mechanisms of cancer progression and metastasis, and demonstration of such mechanisms would provide multiple insights into therapeutic intervention.

Taichiro Nonaka, Louisiana State University Health Sciences Center – Shreveport, United States of America