DR-458 Whole genome sequencing for the investigation of novel genomic biomarkers in cancer

Cancer is caused by stepwise changes in the DNA sequence of the cell genome. In recent years, many common oncogenic driver mutations have become successful targets for cancer treatment. Yet, much research must still be done for cancers caused by rare driver mutations and other less-studied genomic alterations. This project focuses on analyzing whole-genome and RNA sequencing data from muti-cancer, multi-stage cohorts to identify novel cancer-driving abnormalities, determine their etiology and clinical impact, and assess their response to treatments so that early diagnosis and better therapeutic options can be made possible for cancer patients who lack currently treatable mutations.

Kenichi Yoshida, National Cancer Center, Japan