DR-536 Deciphering selection patterns in somatic copy-number events

Changes in DNA copy-number are a key feature of cancer and play an important role in tumor development and progression. However, observed copy-number profiles do not directly reveal the underlying genomic events, limiting our ability to understand the evolutionary forces shaping cancer genomes. We are developing SPICE (Selection Patterns In somatic Copy-number Events), our computational framework for reconstructing the underlying events from genomic sequencing data obtained from patients and healthy controls. By uncovering the selective processes driving cancer evolution, SPICE may ultimately contribute to the identification of new therapeutic targets and support the development of more effective, personalized cancer treatments.

Roland Schwarz, University Hospital Cologne, Germany