Early technology assessment of using whole genome sequencing in personalized oncology

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Early technology assessment of using whole genome sequencing in personalized oncology

25-06-2026

Martijn Simons, Michiel Van De Ven, Veerle Coupé, Manuela Joore, Maarten IJzerman, Erik Koffijberg, Geert Frederix, Carin Uyl – De …

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A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage

25-06-2026

Xueqing Zou, Gene Ching Chiek Koh, Arjun Scott Nanda, Andrea Degasperi, Katie Urgo, Theodoros I. Roumeliotis, Chukwuma A. Agu, Cherif …

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Limited evolution of the actionable metastatic cancer genome under therapeutic pressure

24-06-2026

Joris Van De Haar, Louisa R. Hoes, Paul Roepman, Martijn P. Lolkema, Henk M. W. Verheul, Hans Gelderblom, Adrianus J. …

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Radiotherapy is associated with a deletion signature that contributes to poor outcomes in patients with cancer

24-06-2026

Emre Kocakavuk, Kevin J. Anderson, Frederick S. Varn, Kevin C. Johnson, Samirkumar B. Amin, Erik. P. Sulman, Martijn P. Lolkema, …

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RET Fluorescence In Situ Hybridization Analysis Is a Sensitive but Highly Unspecific Screening Method for RET Fusions in Lung Cancer

24-06-2026

Teodora Radonic, W.R.R. Geurts-Giele, Kris G. Samsom, Guido M.J. M. Roemen, Jan H. Von Der Thüsen, Erik Thunnissen, Isabelle C. …

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Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients

24-06-2026

Jurrian K. De Kanter, Flavia Peci, Eline Bertrums, Axel Rosendahl Huber, Anaïs Van Leeuwen, Markus J. Van Roosmalen, Freek Manders, …

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The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets

23-06-2026

Job Van Riet, Harmen J. G. Van De Werken, Edwin Cuppen, Ferry A. L. M. Eskens, Margot Tesselaar, Linde M. …

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Predicting pathogenic non-coding SVs disrupting the 3D genome in 1646 whole cancer genomes using multiple instance learning

23-06-2026

Marleen M. Nieboer, Luan Nguyen & Jeroen De Ridder Scientific Reports, 2021, DOI

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The impact of rare germline variants on human somatic mutation processes

23-06-2026

Mischan Vali Pour, Ben Lehner & Fran Supek , 2021, DOI

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Micro-costing diagnostics in oncology: from single-gene testing to whole- genome sequencing

23-06-2026

Clémence T. B. Pasmans, Bastiaan B. J. Tops, Elisabeth M. P. Steeghs, Veerle M. H. Coupé, Katrien Grünberg, Eiko K …

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Prospective experimental treatment of colorectal cancer patients based on organoid drug responses

22-06-2026

S.N. Ooft, F. Weeber, L. Schipper, K.K. Dijkstra, C.M. McLean, S. Kaing, J. Van De Haar, W. Prevoo, E. Van …

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Patients with Biallelic BRCA1/2 Inactivation Respond to Olaparib Treatment Across Histologic Tumor Types

22-06-2026

Hanneke Van Der Wijngaart, Louisa R. Hoes, J. Maxime Van Berge Henegouwen, Daphne L. Van Der Velden, Laurien J. Zeverijn, …

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