A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage
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A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage
Xueqing Zou, Gene Ching Chiek Koh, Arjun Scott Nanda, Andrea Degasperi, Katie Urgo, Theodoros I. Roumeliotis, Chukwuma A. Agu, Cherif …
VIRUSBreakend: Viral Integration Recognition Using Single Breakends
Daniel L Cameron, Nina Jacobs, Paul Roepman, Peter Priestley, Edwin Cuppen, Anthony T Papenfuss & Tobias Marschall Bioinformatics, 2021, DOI
GRIDSS2: comprehensive characterisation of somatic structural variation using single breakend variants and structural variant phasing
Daniel L. Cameron, Jonathan Baber, Charles Shale, Jose Espejo Valle-Inclan, Nicolle Besselink, Arne Van Hoeck, Roel Janssen, Edwin Cuppen, Peter …
Radiotherapy is associated with a deletion signature that contributes to poor outcomes in patients with cancer
Emre Kocakavuk, Kevin J. Anderson, Frederick S. Varn, Kevin C. Johnson, Samirkumar B. Amin, Erik. P. Sulman, Martijn P. Lolkema, …
Limited evolution of the actionable metastatic cancer genome under therapeutic pressure
Joris Van De Haar, Louisa R. Hoes, Paul Roepman, Martijn P. Lolkema, Henk M. W. Verheul, Hans Gelderblom, Adrianus J. …
Early technology assessment of using whole genome sequencing in personalized oncology
Martijn Simons, Michiel Van De Ven, Veerle Coupé, Manuela Joore, Maarten IJzerman, Erik Koffijberg, Geert Frederix, Carin Uyl – De …
Driver mutations occur frequently in metastases of well‐differentiated small intestine neuroendocrine tumours
Kris G Samsom, Sonja Levy, Linde M Van Veenendaal, Paul Roepman, Liudmila L Kodach, Neeltje Steeghs, Gerlof D Valk, M …
Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features
Pauline A. J. Mendelaar, Marcel Smid, Job Van Riet, Lindsay Angus, Mariette Labots, Neeltje Steeghs, Mathijs P. Hendriks, Geert A. …
RET Fluorescence In Situ Hybridization Analysis Is a Sensitive but Highly Unspecific Screening Method for RET Fusions in Lung Cancer
Teodora Radonic, W.R.R. Geurts-Giele, Kris G. Samsom, Guido M.J. M. Roemen, Jan H. Von Der Thüsen, Erik Thunnissen, Isabelle C. …
A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage
Xueqing Zou, Gene Ching Chiek Koh, Arjun Scott Nanda, Andrea Degasperi, Katie Urgo, Theodoros I. Roumeliotis, Chukwuma A. Agu, Cherif …
Clinical Validation of Whole Genome Sequencing for Cancer Diagnostics
Paul Roepman, Ewart De Bruijn, Stef Van Lieshout, Lieke Schoenmaker, Mirjam C. Boelens, Hendrikus J. Dubbink, Willemina R.R. Geurts-Giele, Floris …
VIRUSBreakend: Viral Integration Recognition Using Single Breakends
Daniel L Cameron, Nina Jacobs, Paul Roepman, Peter Priestley, Edwin Cuppen, Anthony T Papenfuss & Tobias Marschall Bioinformatics, 2021, DOI
Deze complete DNA-test maakt de individuele behandeling mogelijk en beperkt daarmee onwenselijke bijwerkingen.