“A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage”

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“A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage”

04-08-2022

Xueqing Zou, Gene Ching Chiek Koh, Arjun Scott Nanda, Andrea Degasperi, Katie Urgo, Theodoros I. Roumeliotis, Chukwuma A. Agu, Cherif …

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RET Fluorescence In Situ Hybridization Analysis Is a Sensitive but Highly Unspecific Screening Method for RET Fusions in Lung Cancer

04-08-2022

Teodora Radonic, MD, PhD, W. R. R. Geurts-Giele, PhD,b Kris G. Samsom, MD, Guido M. J. M. Roemen, BSc,Jan H. …

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Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features

04-08-2022

Pauline A. J. Mendelaar, Marcel Smid, Job van Riet, Lindsay Angus, Mariette Labots, Neeltje Steeghs, Mathijs P. Hendriks, Geert A. …

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Driver mutations occur frequently in metastases of well‐differentiated small intestine neuroendocrine tumours

04-08-2022

Samsom K G, Levy S, van Veenendaal L M, Roepman P, Kodach L L, Steeghs N, Valk G D, Dercksen …

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In silico saturation mutagenesis of cancer genes

04-08-2022

Ferran Muiños, Francisco Martínez-Jiménez, Oriol Pich, Abel Gonzalez-Perez, Nuria Lopez-Bigas Nature July 8, 2021 PMID: 34321661

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A kinome‑centered CRISPR‑Cas9 screen identifies activated BRAF to modulate enzalutamide resistance with potential therapeutic implications in BRAF‑mutated prostate cancer

04-08-2022

Sander A. L. Palit, Jeroen van Dorp, Daniel Vis, Cor Lieftink, Simon Linder, Roderick Beijersbergen, Andries M. Bergman, Wilbert Zwart, …

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Learning mutational signatures and their multidimensional genomic properties with TensorSignatures

04-08-2022

Harald Vöhringer, Arne Van Hoeck, Edwin Cuppen, Moritz Gerstung Nature Communications June 15, 2021 PMID: 34131135

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Radiotherapy is associated with a deletion signature that contributes to poor outcomes in patients with cancer

04-08-2022

Emre Kocakavuk, Kevin J. Anderson, Frederick S. Varn, Kevin C. Johnson, Samirkumar B. Amin, Erik. P. Sulman, Martijn P. Lolkema, …

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VIRUSBreakend: Viral Integration Recognition Using Single Breakends

04-08-2022

Daniel L. Cameron, Nina Jacobs, Paul Roepman, Peter Priestley, Edwin Cuppen, Anthony T. Papenfuss Bioinformatics May 11, 2021 PMID: 33973999

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Predicting patient response with models trained on cell lines and patient-derived xenografts by nonlinear transfer learning

04-08-2022

Soufiane M. C. Mourragui, Marco Loog, Daniel J. Vis, Kat Moore, Anna G. Manjon, Mark A. van de Wiel, eMarcel …

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Patients with bi-allelic BRCA1/2 inactivation respond to olaparib treatment across histologic tumor types

04-08-2022

Hanneke van der Wijngaart, Louisa R. Hoes, J. Maxime van Berge Henegouwen, Daphne L. van der Velden, Laurien J. Zeverijn, …

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Evaluation of the Khorana, PROTECHT, and 5-SNP scores for prediction of venous thromboembolism in patients with cancer

04-08-2022

Noori A. M. Guman, Roos J. van Geffen, Frits I. Mulder, Thijs F. van Haaps, Vahram Hovsepjan, Mariette Labots, Geert …

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