Prior therapy defines mutation profiles in childhood cancer at relapse

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Prior therapy defines mutation profiles in childhood cancer at relapse

08-08-2026

Mehdi Layeghifard, Marcos Díaz-Gay, Erik N. Bergstrom, Mathepan J. Mahendralingam, Nicholas Light, Sasha Blay, Joshua O. Nash, Nathaniel D. Anderson, …

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Towards an ecosystem of clinical decision support tools for precision cancer medicine

08-08-2026

Sigve Nakken, Anders Edsjö, Janne Lehtiö, Vigdis Nygaard, Paul Roepman, Richard Rosenquist, Hege G. Russnes, Albrecht Stenzinger, David Tamborero, Sen …

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Prospective evaluation of genomics-guided off-label treatment

08-08-2026

K. Verkerk, A. C. Spiekman, S. F. Haj Mohammad, F. A. J. Verbeek, H. Timmer, M. A. Van Maren, L. …

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Gene mutant dosage is associated with prognosis and metastatic tropism in 60,000 clinical cancer samples

08-08-2026

Nicola Calonaci, Eriseld Krasniqi, Daniel Colic, Stefano Scalera, Giorgia Gandolfi, Salvatore Milite, Konstantin Bräutigam, Andrea Sottoriva, Trevor A. Graham, Leonardo …

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Disruption of the structural maintenance of chromosomes 5/6 complex enables tumor mutagenesis

08-08-2026

Thi Tran, Jiayi Fan, Xiaolan Zhao & Abby M Green NAR Cancer, 2026, DOI

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Systematic identification of genomic nonresponse biomarkers to cancer therapies

08-08-2026

J. Usset, J. De Ligt, S. Roerink, P. Roepman, E. Cuppen & F. Martínez-Jiménez ESMO Real World DATA and DIGITAL …

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Germline haploinsufficiency of MUTYH causes mutational signature SBS18 in multiple tumour types and specifically raises colorectal cancer risk

08-08-2026

Kitty Sherwood, Juan Fernandez-Tajes, Güler Gül, Steve Thorn, Joseph C. Ward, James F. Wilson, Claire Palles, D. Timothy Bishop, Richard …

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Statescope: an integrative deconvolution framework for discovering cell states in tumors

08-08-2026

Jurriaan Janssen, Mischa F. B. Steketee, Aryamaan Bose, Saskia Van Asten, Paul P. Eijk, Frederike Dijk, Arantza Farina Sarasqueta, Febe …

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Emergence and tandem repeat-mediated elongation of a translated de novo open reading frame in human oncogenic RNA gene VPS9D1-AS1 (MYU)

08-08-2026

Lin Chou, Shu-Ting Cho, Jiwon Lee, David Laub, Douglas Meyer, Hannah Carter, Anne-Ruxandra Carvunis & Claudio Zz Casola Genome Biology …

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Real-world clinical utility of tumor whole-genome sequencing in solid cancers

08-08-2026

Jeffrey Van Putten, Petur Snaebjornsson, Linda J. W. Bosch, Roelof Koster, Paul Roepman, Joseph Usset, Mirjam C. Boelens, Tom Van …

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Oncogenes and tumor suppressor genes are enriched in stop-loss mutations generating protein extensions

08-08-2026

Lilian M. Boll, Joan Antoni Martorell, Nafiseh Khelghati, Marta E. Camarena, Clara Vianello, Juan Carlos García-Soriano, Eva Santamaría, Idoia Artoleta, …

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Tumor Whole-Genome Sequencing for Prediction of Venous Thromboembolism in Patients With Metastasized Solid Cancer

08-08-2026

Frits I. Mulder, Noori A.M. Guman, Job Van Riet, Roos J. Van Geffen, Thijs F. Van Haaps, Vahram Hovsepjan, Hanneke …

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