Optimized whole-genome sequencing workflow for tumor diagnostics in routine pathology practice

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Optimized whole-genome sequencing workflow for tumor diagnostics in routine pathology practice

26-02-2024

Kris G. Samsom, Linda J. W. Bosch, Luuk J. Schipper, Daoin Schout, Paul Roepman, Mirjam C. Boelens, Ferry Lalezari, Elisabeth …

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Tumour mutations in long noncoding RNAs enhance cell fitness

26-02-2024

Roberta Esposito, Andrés Lanzós, Taisia Polidori, Hugo Guillen-Ramirez, Bernard Mefi Merlin, Lia Mela, Eugenio Zoni, Isabel Büchi, Lusine Hovhannisyan, Finn …

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A Compendium of AR Splice Variants in Metastatic Castration-Resistant Prostate Cancer

13-12-2023

Khrystany T. Isebia, Martijn P. Lolkema, Guido Jenster, Ronald De Wit, John W. M. Martens, Job Van Riet International Journal …

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Copy number footprints of platinum-based anticancer therapies

13-12-2023

Santiago Gonzalez, Nuria Lopez-Bigas, Abel Gonzalez-Perez, Dmitry A. Gordenin PLOS Genetics, 2023, DOI: 10.1371/journal.pgen.1010634

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Discovering cryptic splice mutations in cancers via a deep neural network framework

13-12-2023

Raphaël Teboul, Michalina Grabias, Jessica Zucman-Rossi, Eric Letouzé NAR Cancer, 2023, DOI: 10.1093/narcan/zcad014

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ERα-associated translocations underlie oncogene amplifications in breast cancer

13-12-2023

Jake June-Koo Lee, Youngsook Lucy Jung, Taek-Chin Cheong, Jose Espejo Valle-Inclan, Chong Chu, Doga C. Gulhan, Viktor Ljungström, Hu Jin, …

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Efficacy, safety and biomarker analysis of durvalumab in patients with mismatch-repair deficient or microsatellite instability-high solid tumours

13-12-2023

Birgit S. Geurts, Thomas W. Battaglia, J. Maxime Van Berge Henegouwen, Laurien J. Zeverijn, Gijs F. De Wit, Louisa R. …

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Genetic immune escape landscape in primary and metastatic cancer

13-12-2023

Francisco Martínez-Jiménez, Peter Priestley, Charles Shale, Jonathan Baber, Erik Rozemuller, Edwin Cuppen Nature Genetics, May 10 2023, DOI: 10.1038/s41588-023-01367-1

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Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivity

13-12-2023

Kathleen E. Houlahan, Aziz Khan, Noah F Greenwald, Robert B. West, Michael Angelo, Christina Curtis NA, 2023, DOI: 10.1101/2023.03.15.532870

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Heritable defects in telomere and mitotic function selectively predispose to sarcomas

13-12-2023

Mandy L. Ballinger, Swetansu Pattnaik, Piyushkumar A. Mundra, Milita Zaheed, Emma Rath, Peter Priestley, Jonathan Baber, Isabelle Ray-Coquard, Nicholas Isambert, …

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Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors

13-12-2023

Luis Zapata, Giulio Caravagna, Marc J. Williams, Eszter Lakatos, Khalid AbdulJabbar, Benjamin Werner, Diego Chowell, Chela James, Lucie Gourmet, Salvatore …

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Mutational processes of tobacco smoking and APOBEC activity generate protein-truncating mutations in cancer genomes

13-12-2023

Nina Adler, Alexander T. Bahcheli, Kevin Cheng, Khalid N. Al-Zahrani, Mykhaylo Slobodyanyuk, Diogo Pellegrina, Daniel Schramek, Jüri Reimand NA, 2023, …

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