Validation of HER2 Status in Whole Genome Sequencing Data of Breast Cancers with the Ploidy-Corrected Copy Number Approach

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Validation of HER2 Status in Whole Genome Sequencing Data of Breast Cancers with the Ploidy-Corrected Copy Number Approach

26-02-2024

Marzena Wojtaszewska, Rafał Stępień, Alicja Woźna, Maciej Piernik, Pawel Sztromwasser, Maciej Dąbrowski, Michał Gniot, Sławomir Szymański, Maciej Socha, Piotr Kasprzak, …

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Trastuzumab and pertuzumab combination therapy for advanced pre-treated HER2 exon 20-mutated non-small cell lung cancer

26-02-2024

J.M. Van Berge Henegouwen, M. Jebbink, L.R. Hoes, H. Van Der Wijngaart, L.J. Zeverijn, D.L. Van Der Velden, P. Roepman, …

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Temporal Dissection of Altered Pathways during the Evolution of Cancer

26-02-2024

Johanne Ahrenfeldt, Ditte S. Christensen, Mateo Sokač, Judit Kisistók, Nicholas McGranahan, Nicolai J. Birkbak NA, 2022, DOI: 10.20944/preprints202210.0470.v1

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Study protocol of the GLOW study: maximising treatment options for recurrent glioblastoma patients by whole genome sequencing-based diagnostics—a prospective multicenter cohort study

26-02-2024

Mark P. Van Opijnen, Marike L. D. Broekman, Filip Y. F. De Vos, Edwin Cuppen, Jacobus J. M. Van Der …

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Lost by Transcription: Fork Failures, Elevated Expression, and Clinical Consequences Related to Deletions in Metastatic Colorectal Cancer

26-02-2024

Marcel Smid, Saskia M. Wilting, John W. M. Martens International Journal of Molecular Sciences, 2022, DOI: 10.3390/ijms23095080

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Integrative analysis of KRAS wildtype metastatic pancreatic ductal adenocarcinoma reveals mutation and expression-based similarities to cholangiocarcinoma

26-02-2024

James T. Topham, Erica S. Tsang, Joanna M. Karasinska, Andrew Metcalfe, Hassan Ali, Steve E. Kalloger, Veronika Csizmok, Laura M. …

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Implementation of Whole-Genome and Transcriptome Sequencing Into Clinical Cancer Care

26-02-2024

Edwin Cuppen, Olivier Elemento, Richard Rosenquist, Svetlana Nikic, Maarten IJzerman, Isabelle Durand Zaleski, Geert Frederix, Lars-Åke Levin, Charles G. Mullighan, …

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Impact of molecular tumour board discussion on targeted therapy allocation in advanced prostate cancer

26-02-2024

Peter H. J. Slootbeek, Iris S. H. Kloots, Minke Smits, Inge M. Van Oort, Winald R. Gerritsen, Jack A. Schalken, …

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High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer

26-02-2024

Marta Palafox, Laia Monserrat, Meritxell Bellet, Guillermo Villacampa, Abel Gonzalez-Perez, Mafalda Oliveira, Fara Brasó-Maristany, Nusaibah Ibrahimi, Srinivasaraghavan Kannan, Leonardo Mina, …

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Germline determinants of the prostate tumor genome

26-02-2024

Kathleen E. Houlahan, Jiapei Yuan, Tommer Schwarz, Julie Livingstone, Natalie S. Fox, Weerachai Jaratlerdsiri, Job Van Riet, Kodi Taraszka, Natalie …

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Genome-wide mapping of somatic mutation rates uncovers drivers of cancer

26-02-2024

Maxwell A. Sherman, Adam U. Yaari, Oliver Priebe, Felix Dietlein, Po-Ru Loh, Bonnie Berger Nature Biotechnology, 2022, DOI: 10.1038/s41587-022-01353-8

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DBFE: Distribution-based feature extraction from copy number and structural variants in whole-genome data

26-02-2024

Maciej Piernik, Dariusz Brzezinski, Pawel Sztromwasser, Klaudia Pacewicz, Weronika Majer-Burman, Michal Gniot, Dawid Sielski, Alicja Wozna, Pawel Zawadzki NA, 2022, …

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