Signatures 1 and 17 show increased propensity to create mutational hotspots in the human genome

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Signatures 1 and 17 show increased propensity to create mutational hotspots in the human genome

22-09-2022

Claudia Arnedo-Pac, Ferran Muiños, Abel Gonzalez-Perez & Nuria Lopez-Bigas BioRxiv, September 19 2022, doi: https://doi.org/10.1101/2022.09.14.507952

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Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

11-08-2022

Daniel Zingg, Jinhyuk Bhin, Julia Yemelyanenko, Sjors M. Kas, Frank Rolfs, Catrin Lutz, Jessica K. Lee, Sjoerd Klarenbeek, Ian M. …

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Comprehensive Molecular Characterization Reveals Genomic and Transcriptomic Subtypes of Metastatic Urothelial Carcinoma

04-08-2022

J. Alberto Nakauma-Gonzáleza, Maud Rijnders, Job van Riet, Michiel S.van der Heijden, Jens Voortman, EdwinCuppen, Niven Mehra, Sandra van Wilpe, …

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Genomics – Guided Treatment of Rare Cancer Patients in DRUP

04-08-2022

L.R. Hoes, J.M. van Berge Henegouwen, H. van der Wijngaart, L.J. Zeverijn, D.L. van der Velden, J. van de Haar, …

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Clinical impact of prospective whole genome sequencing in sarcoma patients

04-08-2022

L.J. Schipper, K. Monkhorst, K.G. Samsom, L.J.W. Bosch, P. Snaebjornsson, H. van Boven, P. Roepman, L.E. van der Kolk, W.J. …

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T Cell-to-Stroma Enrichment (TSE) score: a gene expression metric that predicts response to immune checkpoint inhibitors in patients with urothelial cancer

04-08-2022

Maud Rijnders, J. Alberto Nakauma-González, Debbie G.J. Robbrecht, Alberto Gil-Jimenez, Maureen J.B. Aarts, Joost L. Boormans, Paul Hamberg, Michiel S. …

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Personalized selection of experimental treatment in patients with advanced solid cancer is feasible using Whole Genome Sequencing

04-08-2022

M.A. Pruis, F.H. Groenendijk, K.S. Badloe, A. van Puffelen, D. Robbrecht, W.N.M. Dinjens, S. Sleijfer, A.C. Dingemans, J.H. von der …

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Genomic and transcriptomic landscape of advanced renal cell cancer to individualize treatment strategy

04-08-2022

K. de Joode, W.S. van de Geer, G.J.L.H. van Leenders, P. Hamberg, H.M. Westgeest, A. Beeker, S.F. Oosting, J.M. van …

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Substitution mutational signatures in whole-genome–sequenced cancers in the UK population

04-08-2022

Andrea Degasperi, Xueqing Zou, Tauanne Dias Amarante, Andrea Martinez-Martinez, Gene Ching Chiek Koh, João M. L. Dias, Laura Heskin, Lucia …

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Delivering precision oncology to cancer patients

04-08-2022

Joaquin Mateo, Lotte Steuten, Philippe Aftimos, Fabrice André, Mark Davies, Elena Garralda, Jan Geissler, Don Husereau, Iciar Martinez-Lopez, Nicola Normanno, …

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Genome-wide analysis of somatic noncoding mutation patterns in cancer

04-08-2022

Felix Dietlein, Alex B. Wang, Fagre, Anran Tang, Nicolle J. M. Besselink, Cuppen, Chunliang Li, R. Sunyaev, T. Neal, Eliezer …

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Unscrambling cancer genomes via integrated analysis of structural variation and copy number

04-08-2022

Charles Shale, Daniel L. Cameron, Jonathan Baber, Marie Wong, Mark J. Cowley, Anthony T. Papenfuss, Edwin Cuppen, Peter Priestley Cell …

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