Study protocol of the GLOW study: maximising treatment options for recurrent glioblastoma patients by whole genome sequencing-based diagnostics—a prospective multicenter cohort study

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Study protocol of the GLOW study: maximising treatment options for recurrent glioblastoma patients by whole genome sequencing-based diagnostics—a prospective multicenter cohort study

25-10-2026

Mark P. Van Opijnen, Marike L. D. Broekman, Filip Y. F. De Vos, Edwin Cuppen, Jacobus J. M. Van Der …

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Comprehensive Molecular Characterization Reveals Genomic and Transcriptomic Subtypes of Metastatic Urothelial Carcinoma

25-10-2026

J. Alberto Nakauma-González, Maud Rijnders, Job Van Riet, Michiel S. Van Der Heijden, Jens Voortman, Edwin Cuppen, Niven Mehra, Sandra …

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Complete genomic characterization in patients with cancer of unknown primary origin in routine diagnostics

25-10-2026

L.J. Schipper, K.G. Samsom, P. Snaebjornsson, T. Battaglia, L.J.W. Bosch, F. Lalezari, P. Priestley, C. Shale, A.J. Van Den Broek, …

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Validation of HER2 Status in Whole Genome Sequencing Data of Breast Cancers with the Ploidy-Corrected Copy Number Approach

25-10-2026

Marzena Wojtaszewska, Rafał Stępień, Alicja Woźna, Maciej Piernik, Pawel Sztromwasser, Maciej Dąbrowski, Michał Gniot, Sławomir Szymański, Maciej Socha, Piotr Kasprzak, …

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Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation features

25-10-2026

Luan Nguyen, Arne Van Hoeck & Edwin Cuppen Nature Communications, 2022, DOI

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Recurrent exon-deleting activating mutations in AHR act as drivers of urinary tract cancer

25-10-2026

Judith M. Vlaar, Anouska Borgman, Eric Kalkhoven, Denise Westland, Nicolle Besselink, Charles Shale, Bishoy M. Faltas, Peter Priestley, Ewart Kuijk …

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Apolipoprotein B mRNA-Editing Catalytic Polypeptide-Like–Induced Protein Changes in Estrogen Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Breast Cancer Throughout Disease Progression

25-10-2026

Manouk K. Bos, Marcel Smid, Stefan Sleijfer & John W. M. Martens JCO Precision Oncology, 2022, DOI

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Impact of molecular tumour board discussion on targeted therapy allocation in advanced prostate cancer

25-10-2026

Peter H. J. Slootbeek, Iris S. H. Kloots, Minke Smits, Inge M. Van Oort, Winald R. Gerritsen, Jack A. Schalken, …

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Integrative analysis of KRAS wildtype metastatic pancreatic ductal adenocarcinoma reveals mutation and expression-based similarities to cholangiocarcinoma

25-10-2026

James T. Topham, Erica S. Tsang, Joanna M. Karasinska, Andrew Metcalfe, Hassan Ali, Steve E. Kalloger, Veronika Csizmok, Laura M. …

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Landscape of driver gene events, biomarkers, and druggable targets identified by whole-genome sequencing of glioblastomas

25-10-2026

Wesley S Van De Geer, Youri Hoogstrate, Kaspar Draaisma, Pierre A Robe, Sander Bins, Ron H J Mathijssen, Pim French, …

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Lost by Transcription: Fork Failures, Elevated Expression, and Clinical Consequences Related to Deletions in Metastatic Colorectal Cancer

25-10-2026

Marcel Smid, Saskia M. Wilting & John W. M. Martens International Journal of Molecular Sciences, 2022, DOI

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Genome-wide mapping of somatic mutation rates uncovers drivers of cancer

25-10-2026

Maxwell A. Sherman, Adam U. Yaari, Oliver Priebe, Felix Dietlein, Po-Ru Loh & Bonnie Berger Nature Biotechnology, 2022, DOI

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