High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer

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High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer

12-08-2026

Marta Palafox, Laia Monserrat, Meritxell Bellet, Guillermo Villacampa, Abel Gonzalez-Perez, Mafalda Oliveira, Fara Brasó-Maristany, Nusaibah Ibrahimi, Srinivasaraghavan Kannan, Leonardo Mina, …

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Personalised selection of experimental treatment in patients with advanced solid cancer is feasible using whole-genome sequencing

12-08-2026

Melinda A. Pruis, Floris H. Groenendijk, K. Sangeeta Badloe, Andrea Van Puffelen, Debbie Robbrecht, Winand N. M. Dinjens, Stefan Sleijfer, …

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Impact of molecular tumour board discussion on targeted therapy allocation in advanced prostate cancer

12-08-2026

Peter H. J. Slootbeek, Iris S. H. Kloots, Minke Smits, Inge M. Van Oort, Winald R. Gerritsen, Jack A. Schalken, …

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Apolipoprotein B mRNA-Editing Catalytic Polypeptide-Like–Induced Protein Changes in Estrogen Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Breast Cancer Throughout Disease Progression

12-08-2026

Manouk K. Bos, Marcel Smid, Stefan Sleijfer & John W. M. Martens JCO Precision Oncology, 2022, DOI

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Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation features

12-08-2026

Luan Nguyen, Arne Van Hoeck & Edwin Cuppen Nature Communications, 2022, DOI

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A multi-platform reference for somatic structural variation detection

12-08-2026

Jose Espejo Valle-Inclan, Nicolle J.M. Besselink, Ewart De Bruijn, Daniel L. Cameron, Jana Ebler, Joachim Kutzera, Stef Van Lieshout, Tobias …

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Implementation of Whole-Genome and Transcriptome Sequencing Into Clinical Cancer Care

12-08-2026

Edwin Cuppen, Olivier Elemento, Richard Rosenquist, Svetlana Nikic, Maarten IJzerman, Isabelle Durand Zaleski, Geert Frederix, Lars-Åke Levin, Charles G. Mullighan, …

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Clinical Impact of Prospective Whole Genome Sequencing in Sarcoma Patients

12-08-2026

Luuk J. Schipper, Kim Monkhorst, Kris G. Samsom, Linda J.W. Bosch, Petur Snaebjornsson, Hester Van Boven, Paul Roepman, Lizet E. …

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Unscrambling cancer genomes via integrated analysis of structural variation and copy number

12-08-2026

Charles Shale, Daniel L. Cameron, Jonathan Baber, Marie Wong, Mark J. Cowley, Anthony T. Papenfuss, Edwin Cuppen & Peter Priestley …

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Substitution mutational signatures in whole-genome–sequenced cancers in the UK population

12-08-2026

Andrea Degasperi, Xueqing Zou, Tauanne Dias Amarante, Andrea Martinez-Martinez, Gene Ching Chiek Koh, João M. L. Dias, Laura Heskin, Lucia …

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Study protocol of the GLOW study: maximising treatment options for recurrent glioblastoma patients by whole genome sequencing-based diagnostics—a prospective multicenter cohort study

12-08-2026

Mark P. Van Opijnen, Marike L. D. Broekman, Filip Y. F. De Vos, Edwin Cuppen, Jacobus J. M. Van Der …

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Feasibility of whole‐genome sequencing‐based tumor diagnostics in routine pathology practice

12-08-2026

Kris G Samsom, Luuk J Schipper, Paul Roepman, Linda Jw Bosch, Ferry Lalezari, Elisabeth G Klompenhouwer, Adrianus J De Langen, …

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