DR-277 Somatic mutational signature identification in children with underlying cancer predisposition syndromes
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DR-277 Somatic mutational signature identification in children with underlying cancer predisposition syndromes
Tumors from children with underlying DNA damage response or DNA repair defects often carry somatic mutational footprints that can aid …
DR-267 The whole-genome landscape of advanced biliary tract cancer
Biliary tract cancer (BTC) is a malignancy of the bile ducts (also called cholangiocarcinoma) and gallbladder. BTC is a rare …
DR-007 Mutational migration determined by sequential sequencing
In this project, pairs of tumor biopsies are requested to study evolution of tumors over time. This project may provide …
DR-006 KRAS mutations as a resistance mechanism in gastrointestinal stromal tumors
The researchers will explore the prevalance of mutations in the KRAS gene in GIST patients and study the response to …
DR-005 HMF-Australia
The goal of this request is to enable Hartwig Medical Foundation Australia team to optimize bio informatic tools and pipelines …
DR-004 Molecular background of chemotherapy respons in ovarian cancer
The goal of this project is to identify genetic factors that are involved in chemotherapy resistence in ovarium cancer and …
DR-003 TUMOROID/SENSOR study
The objective of this request is to connect genetic information obtained in the CPCT-02 study and in vitro tumor organoid …
DR-002 MAP3K1 and MAP2K4 mutations as biomarkers of response to EGFR-based therapy in KRAS wild type colon cancer
In this project, data from CRC patients treated with anti-EGFR therapy will be used to identify biomarkers that predict treatement …
DR-001 Liver-specific mutations in metastatic colorectal cancer
The objective of this project is to determine if the microenvironment of metastases influences mutation patterns. The investigators will test …
DR-035 Learning the subtypes of cancer
Histological, immunohistochemical and gene expression markers are routinely used to stratify tumours into clinically distinct subtypes, some of which have …
DR-034 The forgotten cancer genome – the therapeutic impact of germline
To date, translational cancer genomics has focused on somatic genetics, driven by the desire to identify mutated targets that indicate …
DR-032 ctDNA analysis to predict early recurrence after chemoradiation in head and neck squamous cell cancer (HNSCC)
“Patients with head and neck cancer too advanced for surgical resection have a very poor prognosis, despite the currently standard, …
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