DR-016 Detectie van structurele varianten in DNA die van invloed zijn op dikkedarmkanker
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DR-016 Detectie van structurele varianten in DNA die van invloed zijn op dikkedarmkanker
The researchers will study the involvement of structural variation in the tumor genomes of colorectal cancer patients and investigate their …
DR-015 Voorspellers voor respons op standaard chemotherapie bij colorectaal carcinoom
“In this study genetic factors will be explored that may explain response to standard chemotherapy (FOLFOX/CAPOX/Irinotecan/capecitabine) in coloroctal cancer patients. …
DR-014 Verhoging kwaliteit van zorg door doelgerichtere inzet van medicatie in de oncologie
This project is focused on biomarker discovery for specific targeted treatments in breast cancer patients. Specific focus will be on …
DR-013 Genetic causes of resistance to new androgen receptor signaling inhibitors in circulating tumor DNA of metastasized castration-resistant prostate cancer patients
The research question is focused on the improvement and development of novel treatment approaches in prostate cancer patients that have …
DR-012 Phosophoproteomics for therapy response prediction
The goal of this project is to correlate systematic DNA and protein measurement data from the same patients. This pilot …
DR-011 The landscape of structural variation in metastatic prostate cancer samples
This project aims to create a systematic overview of the mutation landscape of metastatic prostate cancer patients with a special …
DR-010 The prevalence and burden of rare deleterious germline variants
The goal of this project is to identify inherited mutations in genes that result in higher chances to develop cancer …
DR-009 Dynamic response assessments to understand responses to immunotherapy in metastatic cancer
The response to check-point inhibitors (immunotherapy) is highly variable between tumor types. The researchers will search for novel biomarkers based …
DR-008 Technology Assessment of Next Generation Sequencing in Personalized Oncology (TANGO)
“This project aims to identify biomarkers that are predictive for response to immunotherapy (check-point inhibitors) in lung cancer patients. As …
DR-065 Network-based analysis to identify metastatic driver pathways
We will analyse the Hartwig Medical Foundation metastatic cohort with advanced network analysis techniques to identify genes and key pathways …
DR-063 Extension of Dutch genome reference by detection, anchoring and functional characterization of non-reference segments
Despite the fact that completion of human genome project that was announced over 15 years ago, our knowledge of human …
DR-062 The genetic profile of malignant pleural mesothelioma (MPM) and response to therapy
Malignant pleural mesothelioma (MPM) is a rare and aggressive malignancy that arises from the mesothelial surfaces of the pleural cavity. …
Kankers zullen steeds vaker voldoen aan de definitie van ‘zeldzaam’ als het gaat om de moleculaire profielen die elke tumor uniek maakt. Hoe meer onderzoek we hiernaar doen, hoe beter we in de toekomst elke patiënt een op maat gemaakte behandeling kunnen aanbieden. Whole genome sequencing en studies als DRUP leveren hier een belangrijke bijdrage aan.