DR-009 Dynamic response assessments to understand responses to immunotherapy in metastatic cancer
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DR-009 Dynamic response assessments to understand responses to immunotherapy in metastatic cancer
The response to check-point inhibitors (immunotherapy) is highly variable between tumor types. The researchers will search for novel biomarkers based …
DR-008 Technology Assessment of Next Generation Sequencing in Personalized Oncology (TANGO)
“This project aims to identify biomarkers that are predictive for response to immunotherapy (check-point inhibitors) in lung cancer patients. As …
DR-065 Network-based analysis to identify metastatic driver pathways
We will analyse the Hartwig Medical Foundation metastatic cohort with advanced network analysis techniques to identify genes and key pathways …
DR-063 Extension of Dutch genome reference by detection, anchoring and functional characterization of non-reference segments
Despite the fact that completion of human genome project that was announced over 15 years ago, our knowledge of human …
DR-062 The genetic profile of malignant pleural mesothelioma (MPM) and response to therapy
Malignant pleural mesothelioma (MPM) is a rare and aggressive malignancy that arises from the mesothelial surfaces of the pleural cavity. …
DR-061 Molecular archaeology of cancer metastases
We aim to apply computational tools to Hartwig Medical Foundation cancer genomes to establish the order in which harmful mutations …
DR-060 Whole genome Sequencing to estimate TEmozolomide Associated Response IN Gliomas (STEARING)
“Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults. Since 2005, standard treatment consists of …
DR-059 The Australian Pancreatic Cancer Atlas Project
In order to enable the next phase of genomic discovery and build a mutational atlas for future Precision Oncology purposes …
DR-058 The genomic landscape of metastatic colorectal cancer and its predictive potential.
The treatment of inoperable metastatic colorectal cancer consists of systemic treatment through chemotherapy with or without additional targeted treatment. Until …
DR-057 Processes regulating cancer metastasis and disease progression
We aim to identify and characterize the molecular and cellular factors that distinguish cancer cells that metastasize from cancer cells …
DR-056 The identification and characterization of predictive markers of therapy response in metastatic breast cancer by assessing cell heterogeneity in RNA sequencing data.
The use of molecular pathology (for example DNA-testing) has increasingly allowed the selection of the right treatment for the right …
DR-054 Using recurrent somatic mutations to provide new insights into mutagenesis in cancer
The changes to the DNA (mutations) found in a tumor are expected to be largely unique to each tumor as …
Unieke dataset Hartwig heeft onze visie op uitgezaaide kanker verrijkt.