DR-061 Molecular archaeology of cancer metastases
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DR-061 Molecular archaeology of cancer metastases
We aim to apply computational tools to Hartwig Medical Foundation cancer genomes to establish the order in which harmful mutations …
DR-060 Whole genome Sequencing to estimate TEmozolomide Associated Response IN Gliomas (STEARING)
“Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults. Since 2005, standard treatment consists of …
DR-059 The Australian Pancreatic Cancer Atlas Project
In order to enable the next phase of genomic discovery and build a mutational atlas for future Precision Oncology purposes …
DR-058 The genomic landscape of metastatic colorectal cancer and its predictive potential.
The treatment of inoperable metastatic colorectal cancer consists of systemic treatment through chemotherapy with or without additional targeted treatment. Until …
DR-057 Processes regulating cancer metastasis and disease progression
We aim to identify and characterize the molecular and cellular factors that distinguish cancer cells that metastasize from cancer cells …
DR-056 The identification and characterization of predictive markers of therapy response in metastatic breast cancer by assessing cell heterogeneity in RNA sequencing data.
The use of molecular pathology (for example DNA-testing) has increasingly allowed the selection of the right treatment for the right …
DR-054 Using recurrent somatic mutations to provide new insights into mutagenesis in cancer
The changes to the DNA (mutations) found in a tumor are expected to be largely unique to each tumor as …
DR-053 Analysis of Cancer Evolutionary Processes
We use whole cancer genome sequences to understand the order of mutations in cancer development so that we can infer …
DR-052 Measuring the evolutionary dynamics of positive and negative selection in metastatic cancers
In this project we aim at combining mathematical modelling of tumor evolution with cancer genomic data to measure fundamental evolutionary …
DR-050 Discovery and Clincal Characterization of Cancer Driver Mutations in Noncoding regions
Cancer genomes typically harbor a substantial number of somatic mutations. However, only few of these mutations actually contribute to tumor …
DR-044 A pan-cancer catalogue of the mutational footprint of DNA repair deficiencies and their potential as biomarkers of treatment efficacy
“Cancer develops by accumulation of mutations in the DNA of individual cells. In many patients, DNA repair mechanisms are often …
DR-040 Utilizing neoantigens to treat pancreatic cancer
Pancreatic cancer is the fourth leading cause of cancer-realated deaths in the world. Current therapeutic options including chemo-, radio- and …
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