DR-038 Plasticity of estrogen receptor genomics in endometrium tumors
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DR-038 Plasticity of estrogen receptor genomics in endometrium tumors
Endometrium cancer is one of the most common gynecological cancer and accounts for approx. 6% of all cancers in women. …
DR-036 The landscape of somatic genetic aberrations in metastases of neuroendocrine tumors
“Neuroendocrine tumors are rare cancers most often arising in the lungs, pancreas or gastro-intestinal tract. Its behavior can vary greatly …
DR-100 Development of novel diagnostics for personalisation of glioma patient’s therapy based on whole-genome sequencing data and mutational signatures
The main purpose of the research project is to develop new diagnostic biomarkers that will be used for personalised therapy …
DR-097 Molecular mechanisms of interplay between DNA repair pathways in chemotherapy resistance
The main purpose of the research project is to understand the mechanism of interplay between DNA repair pathways associated with …
DR-096 Cisplatin exposure related genomic changes in human germ cell tumors
The nature and impact of genomic changes induced by cisplatin treatment of germ cell tumors is unknown. This is relevant …
DR-091 Organotropism: gaining new insights into the molecular landscape of prostate cancer metastases
While localized prostate cancer can be cured, metastastatic disease is associated with high morbidity and mortality. Prostate cancer typically metastasizes …
DR-089 Tumor genotype and the risk of cancer-associatied venous thromboembolsim: results from 4000 cancer biopsies (PANDORA study)
“Venous thromboembolism (VTE), a venous blood clot, frequently occurs in cancer patients, and substantially affects morbidity, quality of life, and …
DR-088 The genomic landscape of renal cell cancer patients
The introduction of new therapeutic options, i.e. antiangiogenic drugs and immunotherapy, has significantly changed the treatment and perspectives of patients …
DR-087 Pan-cancer investigation of intratumor heterogeneity in primary and metastatic disease
We aim to stratify cancer types by the degree of intratumour heterogeneity demonstrated both between metastases (when the cancer spreads) …
DR-086 Optimalisation of chemotherapy response in metastatic colorectal cancer patients based on a patient-specific cellular composition score.
The treatment of metastatic colorectal cancer (mCRC) is still based on traditional chemotherapies. mCRC is a very heterogeneous disease, and …
DR-085 Germline genetic variants underlying the genomic, transcriptomic and clinical characteristics of metastatic breast cancer
Breast cancer is the most common cancer among women Worldwide. Inherited variants in breast cancer susceptibility genes or other regions …
DR-084 Defining bacteria-induced mutational signatures in human tumors
Numerous environmental triggers have been found to leave a footprint on the DNA of human cancers. By treating human cells …
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