DR-069 Variation in mutational processes across the human genome
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DR-069 Variation in mutational processes across the human genome
Cancer is a disease of the genome. Random factors, environmental exposures and also certain biological mechanisms have the potential to …
DR-068 The integration of genomics and transcriptomics using biopsies of metastatic breast cancer patients
Breast cancer is the most common malignancy among women wordwide. To reveal the genomic landscape of metastatic breast cancer, we …
DR-067 Virus-Induced Cell-Cell Fusion as a Driver of Metastasis
“Many viruses that commonly infect humans have been found to fuse cells. Evidence suggests that the products of cell fusion …
DR-066 Googling the cancer genome
Cancer affects millions of people worldwide. Current DNA sequencing technologies allow routine screening of patients for cancer-associated mutations that can …
DR-090 Phosphoproteomics for therapy response prediction
This project concerns a feasibility study, in which tumor biopsies collected in different hospitals in the CPCT-02 trial will be …
DR-073 Making HMF colorectal cancer data accessible for the HMF CRC focus group through cBioPortal
“Colorectal cancer (CRC) is the second most common cause of cancer death worldwide. Cancer is caused by DNA alterations. Detailed …
DR-072 Chromosomal breakpoints in colorectal cancer
“Purpose: Colorectal cancer (CRC) is the second most common cause of cancer death worldwide. Cancer is caused by DNA alterations. …
DR-055 The whole-genome landscape of advanced biliary tract cancer
Biliary tract cancer (BTC) is malignancy of bile ducts (also called cholangiocarcinoma) and gallbladder. BTC is a rare malignancy in …
DR-112 Somatic mutations and germline variants at Estrogen Receptor / DNA binding sites and their impact on gene expression programs in metastatic breast cancer
Estrogen Receptor is a hormone-responsive protein, responsible for breast tumor growth. We found that DNA-binding specificity can predict treatment response, …
DR-110 Whole-genome mutational patterns
Mutations are generated by endogenous (replication errors) and exogenous processes (UV light). Studying the mutational patterns observed across both genes …
DR-108 Genomic characterisation of Non-Melanoma Skin Cancer
Our group produces WGS data for 100 Non-Melanoma Skin Cancers (NMSC) in order to characterise mutational landscape and driver mutations …
DR-107 Impact of somatic mutations and prostate cancer risk SNPs on enhancer activity, interpatient heterogeneity and responsive gene expression in metastatic prostate cancer
We have mapped in metastatic prostate cancer how genes are being regulated. Now, we aim to combine these results with …
Het feit dat het CPCT het samen met Hartwig Medical Foundation voor elkaar heeft gekregen om data, kennis en kunde van vrijwel alle Nederlandse ziekenhuizen te bundelen, is uniek en krijgt inmiddels ook internationale aandacht.