DR-078 Studying the biology and clonal evolution of the cancer epigenome by integrating somatic alterations with epigenetic maps
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DR-078 Studying the biology and clonal evolution of the cancer epigenome by integrating somatic alterations with epigenetic maps
We aim to stratify cancer types by the degree of intratumour heterogeneity demonstrated both between metastases (when the cancer spreads) …
DR-077 Identification of metastasis-driving long noncoding RNAs
The treatment of metastatic colorectal cancer (mCRC) is still based on traditional chemotherapies. mCRC is a very heterogeneous disease, and …
DR-076 Whole genome Sequencing to estimate TEmozolomide Associated Response IN Gliomas (STEARING)
Breast cancer is the most common cancer among women Worldwide. Inherited variants in breast cancer susceptibility genes or other regions …
DR-075 Measuring the evolutionary dynamics of positive and negative selection in metastatic cancers.
Numerous environmental triggers have been found to leave a footprint on the DNA of human cancers. By treating human cells …
DR-074 Modeling the pan-cancer molecular landscape and predicting drug response in metastatic cancer
Personalized medicine driven treatments in major diseases like non-small cell lung cancer (NSCLC) and melanoma offer important health benefits to …
DR-071 “Characterisation and in-depth analysis of the genome and clinical correlates of metastatic prostate cancer patients for improved patient stratification. DR-071 is an extension of DR-011”
“In this project we aim to use whole genome sequencing data to improve the way we treat patients with prostate …
DR-070 Mutational status of stage IV small intestinal neuroendocrine tumors and its effect on therapy and prognosis
“Small intestinal neuroendocrine tumors (SI-NETs) represent a heterogenous group of rare tumors. At time of diagnosis approximately 50% of patients …
DR-069 Variation in mutational processes across the human genome
Cancer is a disease of the genome. Random factors, environmental exposures and also certain biological mechanisms have the potential to …
DR-068 The integration of genomics and transcriptomics using biopsies of metastatic breast cancer patients
Breast cancer is the most common malignancy among women wordwide. To reveal the genomic landscape of metastatic breast cancer, we …
DR-067 Virus-Induced Cell-Cell Fusion as a Driver of Metastasis
“Many viruses that commonly infect humans have been found to fuse cells. Evidence suggests that the products of cell fusion …
DR-066 Googling the cancer genome
Cancer affects millions of people worldwide. Current DNA sequencing technologies allow routine screening of patients for cancer-associated mutations that can …
DR-090 Phosphoproteomics for therapy response prediction
This project concerns a feasibility study, in which tumor biopsies collected in different hospitals in the CPCT-02 trial will be …
Door WGS hebben we in de moleculaire diagnostiek op onze afdeling een stap gemaakt van de analyse van minder dan 100 genen naar circa 20.000 genen per patiënt. Dat levert ontzettend veel waardevolle informatie, niet alleen voor de patiënt van vandaag, maar ook voor de patiënt van de toekomst.