DR-486 Integrated Analysis of Mitochondrial Somatic Variants, Chromosomal Instability, and Extrachromosomal DNA in Human Metastatic Cancer: A Multi-Omics Approach Using Hartwig Whole Genome Data
- Algoritmes
- Behandeling op maat
- Betaaltitel
- Biomarker
- cfDNA
- DNA
- Educatie
- Geen onderdeel van een categorie
- GENAYA project
- Hartwig Medical Database
- Hartwig Medical Foundation
- Hergebruik data
- Innovatie
- IT
- Kwaliteit
- Lab proces
- Lerend zorgsysteem
- Medicijn
- Moleculaire diagnostiek
- OncoAct
- Onderzoek
- Participerende ziekenhuizen
- Pipeline
- Preventie
- Primaire Tumor Onbekend
- Uitbehandeld
- Verhalen patiënten
- Werken in de cloud
- Wetenschappelijke publicaties
- Whole genome sequencing
- Zeldzame kankers
DR-486 Integrated Analysis of Mitochondrial Somatic Variants, Chromosomal Instability, and Extrachromosomal DNA in Human Metastatic Cancer: A Multi-Omics Approach Using Hartwig Whole Genome Data
Cancer cells accumulate multiple types of genetic damage that work together to make tumors more aggressive and harder to treat. …
DR-480 Biomarker and Pattern Discovery and Validation
When analysing genomic, transcriptomic, epigenetic and clinical data from cancer patients, response to treatment can be related to the occurrence …
DR-473 Investigating the molecular background of rare anogenital sqaumous cell carcinomas, to unveil the tumor driving events in HPV-positive and HPV-negative tumors and find differences and similarities between tumor types.
Penile, vaginal, vulvar, and anal cancer are rare types of (anogenital) cancer, and a lot is unknown about tumor biology. …
DR-484 Analysis of germline mutations to discover novel biomarkers for prognosis and treatment response
This project investigates how inherited (germline) genetic mutations affect cancer outcomes. While some well-known “driver” mutations, such as those in …
DR-483 Characterization of the evolutionary dynamics of mutational signatures for clinically actionable cancer genomics
We aim to decode how cancers mutate their DNA over time and use that knowledge to improve patient care. Using …
DR-501 The stem or differentiated nature of the cell-of-origin of colon cancer
According to the current dogma, colon cancer originates from stem cells. However, we have shown in mouse models that differentiated …
DR-503 Characterizing ABCB1 fusions in drug-resistant cancers
ABCB1 encodes a protein that causes chemotherapy resistance. We aim to determine what causes ABCB1 expression in drug-resistant cancers. This …
DR-494 Analysis of MYC-driven transcriptional programs and genomic mutations linked to immune checkpoint inhibitor resistance in melanoma and non-small cell lung cancer.
Through comprehensive bioinformatic analysis of datasets, the purpose of our project is to identify MYC-dependent signatures and to assess their …
DR-478 Understanding the Abscopal effect in Prostate cancer – Primary and Metastatic Tumour Crosstalk
The project aims to identify immune cell infiltration within metastatic prostate cancer samples and evaluate if radiation therapy modifies these …
DR-492 Whole genome sequencing of small intestinal adenocarcinomas
Small intestinal adenocarcinoma (SIA) is a rare cancer with poor survival outcomes and limited treatment options. Knowledge of its biology …
DR-454 The genomic landscapes of MLH1-mutated and/or CTNNB1-mutated colorectal carcinomas
Colorectal cancer (CRC) is a heterogeneous disease comprising subtypes with distinct clinical and/or molecular characteristics. Roughly, two major categories of …
DR-465 Investigating the role of tandem repeat expansions in cancer risk
This project seeks to use genome sequencing data from tumor samples to look for a specific type of genetic mutation …
De complete DNA-test is een belangrijke stap op weg naar behandeling van vormen van kanker die nu nog niet behandeld kunnen worden met doelgerichte medicijnen.